The striker could make his debut following his £63.5 million transfer from Sporting, but Kai Havertz is selected to lead the attack, as Mikel Arteta makes five changes from the team that defeated Newcastle.
Jakub Kiwior steps in for Riccardo Calafiori at centre-back alongside William Saliba.
In midfield, Declan Rice, Christian Norgaard, and Martin Odegaard replace Ethan Nwaneri, Martin Zubimendi, and Mikel Merino.
Gabriel Martinelli starts on the left wing, taking the place of Leandro Trossard.
Tottenham Starting XI: Vicario; Porro, Romero, Van de Ven, Spence; Bentancur, Sarr, Bergvall; Kudus, Richarlison, Odobert.
Arsenal Starting XI: Raya; White, Kiwior, Saliba, Lewis-Skelly; Rice, Norgaard, Odegaard; Saka, Havertz, Martinelli.
